Elucidating Mechanisms for the Biological Activities of CD46

Abstract

The CD46 protein enables entry into cells of a number of different pathogens, including the measles virus, Neisseria meningitidis (the major cause of meningococcal disease), Neisseria gonorrhoea, Human Herpes Virus 6, and group A streptococcus. In addition, by binding to a key blood component that is often attached to foreign pathogens, CD46 can facilitate binding and entry of other pathogens. As well as facilitating entry of the pathogen, it has recently become apparent that CD46 binding triggers a wide range of responses from the human host. Some of these responses are likely to further facilitate survival and proliferation of the pathogen, but others are more likely to facilitate host def..

Related publications (1)

Ligation of the cell receptor, CD46, alters T cell polarity and response to antigen presentation

J Oliaro, A Pasam, NJ Waterhouse, KA Browne, MJ Ludford-Menting, JA Trapani, SM Russell

2006-12-05

Lymphocyte function in vivo is dictated by multiple external cues, but the integration of different signals is not well understood..